Endocrine Abstracts

Somatuline Autogel® 120 mg (SATG, Ipsen, Sweeden) is a high dose sustained release aqueous gel formulation, supplied in a prefiled syringe and given by deep subcutaneous injection. The aim of this cross-sectional hospital based study, approved by the local ethical committee, was to investigate efficacy and tolerability of SATG given every 4 weeks in patients with active acromegaly.Twenty patients (9f, 11m) aged 42.9±17.8 (range 17&#1...

Patients with hypopitutarism have higher cardiovascular morbidity and mortality rates than general population, as manifested by elevated fasting lipids and insulin resistance. The aim of our study was to evaluate the lipid levels and insulin responses during oral glucose tolerance test (OGTT) in adult onset growth hormone deficiency (AO-GHD), without growth hormone replacement during a follow-up period of seven years. Ten hypopituitary patients with operated non-functioning pi...

A female patient, 34 years old, was referred to endocrinologist, for an incidentally discovered interstellar mass on MR, mild subclinical hypothyroidism and hyperprolactinemia, and irregular menstrual cycles. She was diagnosed with Bloch-Sulzberger syndrome (BSS) in neonatal age. Epilepsy, her most prominent component of BSS, was well controlled but only with triple anticonvulsant therapy (Valproate, Carbamazepine, Clonazepam). She was obese, clinically euthyroid, and exhibite...

Objective: People are at higher risk for malignancy as they get older or have a strong family history of cancer.Aim: To collect family history of cancer in a large cohort of patients with pituitary adenomas (PA) in Outpatient clinic from years 2005–2017.Results: Overall 46% of 1100 patients with PA had a family member affected with cancer. Breast cancer in family members was reported in 15.3% of patients with prolactinomas whi...

Introduction: Pregnancy and lactation-associated osteoporosis (PLO) is a rare condition in which women have fragile fractures associated with significant reduction of BMD during pregnancy or postpartum period.Case report: A 37-year-old female patient was admitted at our Clinic for further investigation of aetiology of osteoporosis in July 2019. Soon after delivery in February 2019 patient had felt left hip and foot pain as well as sharp intensive pain (i...

Introduction: Previous studies reported increased unfavorable metabolic phenotype in patients with active acromegaly.Aim of the study: We studied the metabolic phenotype in unselected cohort of 133 patients with active acromegaly (83 female, 62.4%), diagnosed at Clinic of Endocrinology, University Clinical Center, Belgrade, Serbia in the period 2007–2018. Mean age at diagnosis of acromegaly was 50.5±1.2 years and mean BMI was 28.4±0.4 kg/m...

Introduction: Skeletal complications of acromegaly are among its most persistent and invalidating impacts. Dual-X-ray absorptiometry (DXA) alone might be insufficient or even misleading for bone health assessment in acromegaly.Patients and methods: Patients with acromegaly (N=170) were classified as active (N=104), operatively cured (N=34) or medically controlled (N=32). 57 males and 113 females were included, 52.8 (22...

According to the novel concept bone remodeling is centrally regulated (CNS). Leptin the adipocyte derived hormone acts on hypothalamus and by increasing sympathetic activity acts on osteoblasts to regulate bone formation. In patients with schizophrenia several factors have influence on bone metabolism. Schizophrenia per se, as a disease of central nervous system is associated with increased occurence of osteoporosis. Hyperprolactinemia as consequence of antipsychotic tr...

Spontaneous subarahnoid hemorrhage (SAH) is a recently identified risk factor for hipopituitarism, especially growth hormone (GH) and corticotroph deficiencies. The aim of this study is to perform the initial screening procedure to identify the patients with increased risk of neuroendocrine dysfunction after SAH in the chronic phase and to identify the possible predictor(s) for neuroendocrine dysfunction. Ninety-one patients (30 males, 61 females), age between 19 and 69 years ...

We have previously shown impaired neuroendocrine responses to ghrelin in patients with AN. The aim of this study was to investigate the metabolic responses during infusions of active ghrelin in severly malnourished patients with AN and compare them with responses of amenorrhoic AN patients who recovered body weight (PRAN) and constitutionally thin subjects (CTS) with regular menstrual cycles and without history of eating disorder and recent weight loss. Study was approved by t...